Diagnosis

Secondary Progressive MS (SPMS)

What it is

Secondary progressive MS is a phase some people move into after years of relapsing-remitting MS. In SPMS, symptoms gradually build up over time, with or without clear relapses in between. The shift from RRMS to SPMS can be slow and hard to pin down exactly.

Why it matters for you

If your care team mentions SPMS, they are describing a change in the pattern of how MS is showing up, not a new disease. Understanding the label helps make that shift in language less confusing.

Questions to ask your doctor

  • Am I showing any signs of progression?
  • Should we discuss switching therapies?
  • Are there new treatments I should know about?
  • How does my disability score compare to last year?
  • Should I see any other specialists?
See all you're due for your yearly check-up questions

Find MS treatment centers near you

MS care is specialized — the center you choose shapes access to DMTs, infusions, and clinical trials. Pick your state to see centers in your area.

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Reviewed by the MS Buddy editorial team · Last updated April 16, 2026
Not medical advice. Always consult your care team.