MS Depression and Mood Research
Updated
Around half of people with MS will have depression at some point in their lives. Depression is more common in people with MS than in the general population. Anxiety is also common. Below is the latest research on depression, anxiety and mood in MS, explained in plain language.
Latest studies
Sep 23, 2026
In MS, support shaped links between sharing and mood
Observational study · 272 Iranian people with MS
In 272 Iranian adults with MS, sharing distress was linked to less anxiety and depression when support felt low, but more when support felt high.
Aug 17, 2025
In MS-like mice, blocking harmful by-products eased pain
Animal study · female mice with an MS-like disease and cells in a dish
In mice with an MS-like disease, blocking harmful by-products reduced pain and anxiety-like behavior. The study did not test these treatments in people with MS.
Aug 7, 2025
Depression-related genes linked to more MS relapses
Observational study · 3,420 people whose MS began with relapses, of European genetic ancestry
Among 3,420 adults with MS, higher inherited depression risk was linked to more relapses. In the US group, it was also linked to disability worsening.



